Pediatric Brain Tumor Laboratory

 

Research Projects

The Pediatric Brain Tumor Lab focuses on 

  1. Elucidating the cellular molecular mechanisms of the leptomeningeal dissemination of pediatric brain tumors such as medulloblastoma and ependymoma
  2. Identifying novel therapeutic agents of leptomeningeal metastases
  3. Unraveling the immunogenic mechanism of oncolytic viral therapy for the treatment of pediatric brain and spine tumors

Personnel

Principal Investigator

Eric M. Thompson, MD

Contact: eric.thompson@duke.edu

 

 

 

 

 

 

 

 

Members

Eric Sankey, MD, Neurosurgery Resident

Eddie Tsvankin, MD, Neurosurgery Resident

Khalima Sadieva, PhD, Lab Technician

Postdoctoral position open

We are looking for a highly motivated post-doctoral associate with a background in cancer biology to share our ongoing research efforts. Knowledge and experience with immunotherapy is also desired. Excellent written and verbal communication in English is required.

Interested candidates for either position should email their application packages to eric.thompson@duke.edu containing the following:

  • Cover letter indicating current and future research interests
  • CV (Curriculum Vitae) including publications
  • Brief description of past research experience and accomplishments
  • Names and contact information of three references

Selected Publications

Stephen Harward, S. Harrison Farber, Michael Malinzak, Oren Becher, Eric M. Thompson. T2-weighted images are superior to other MR image types for the determination of diffuse intrinsic pontine glioma intratumoral heterogeneity. Child’s Nervous System. 2018 34(3):449-455.

Eric M. Thompson, Stephen T. Keir, Talaignair Venkatraman, Christopher Lascola, Kristen W. Yeom, Andrew Nixon, Yingmiao Liu, Daniel Picard, Marc Remke, Darell D. Bigner, Vijay Ramaswamy, Michael D. Taylor. The role of angiogenesis in Group 3 medulloblastoma pathogenesis and survival. Neuro-Oncology, 2017. 19(9):1217-27.

Eric M. Thompson, Sridharan Gururangan, Gerald Grant, Duane Mitchell, John H. Sampson. The Clinical and Financial Impact of a Pediatric Surgical Neuro-Oncology Clinical Trial. Journal of Neuro-Oncology, 2017. 132(1):83-87.

Eric M Thompson, Thomas Hielscher, Eric Bouffet, Marc Remke, Betty Luu, Sridharan Gururangan, Roger E McLendon, Darell D Bigner, Eric S Lipp, Sebastien Perreault, Yoon-Jae Cho, Gerald Grant, Seung-Ki Kim, Seung-Ki Kim, Ji Yeoun Lee, Amulya A Nageswara Rao, Caterina Giannini, Kay Ka Wai Li, Ho-Keung Ng, Yu Yao, Toshihiro Kumabe, Teiji Tominaga, Wieslawa A Grajkowska, Marta Perek-Polnik, David CY Low, Wan Tew Seow, Kenneth TE Chang, Jaume Mora, Ian F Pollack, Ronald L Hamilton, Sarah Leary, Andrew S. Moore, Wendy J. Ingram, Andrew R. Hallahan, Anne Jouvet, Michelle Fèvre-Montange, Alexandre Vasiljevic, Cecile Faure-Conter, Tomoko Shofuda, Naoki Kagawa, Naoya Hashimoto, Nada Jabado, Alexander G Weil, Tenzin Gayden, Takafumi Wataya, Tarek Shalaby, Michael Grotzer, Karel Zitterbart, Jaroslav Sterba, Leos Kren, Tibor Hortobágyi, Almos Klekner, Bognár László, Tímea Pócza, Peter Hauser, Ulrich Schüller, Shin Jung, Woo-Youl Jang, Pim J French, Johan M Kros, Marie-Lise C van Veelen, Luca Massimi, Jeffrey R Leonard, Joshua B Rubin, Rajeev Vibhakar, Lola B Chambless, Michael K Cooper, Reid C Thompson, Claudia C Faria, Alice Carvalho, Sofia Nunes, José Pimentel, Xing Fan, Karin M Muraszko, Enrique López-Aguilar, David Lyden, Livia Garzia, David JH Shih, Noriyuki Kijima, Christian Schneider, Jennifer Adamski, Paul A Northcott, Marcel Kool, David TW Jones, Jennifer A Chan, Ana Nikolic, Maria Luisa Garre, Erwin G Van Meir, Satoru Osuka, Jeffrey J Olson, MD, Arman Jahangiri, Brandyn A. Castro, Nalin Gupta, William A Weiss, Iska Moxon-Emre, Donald J Mabbott, Alvaro Lassaletta, Cynthia E Hawkins, Uri Tabori, James Drake, Abhaya Kulkarni, Peter Dirks, James T Rutka, Andrey Korshunov, Stefan M Pfister, Roger J Packer, Vijay Ramaswamy, Michael D Taylor.  ­Prognostic Value of Medulloblastoma Extent of Resection After Accounting for Molecular Subgroup:  An Integrated Clinical and Molecular Analysis. Lancet Oncology, 2016. 17(4):484-95.

Eric M. Thompson, Gregory L. Pishko, Leslie L. Muldoon, and Edward A. Neuwelt. Inhibition of SUR1 Decreases the Vascular Permeability of Cerebral Metastases. Neoplasia. 2013; 15(5):535-43.

Eric M. Thompson, Nathanial L. Whitney, Y. Jeffery Wu, and Edward A. Neuwelt. Inhibiting αv Integrins Decreases the Malignant Characteristics of Medulloblastoma. Journal of Neurosurgery: Pediatrics. 2013; 11(1):60-7.

Eric M. Thompson, Daniel J. Guillaume, Edit Dosa, Xin Li, Kellie J. Nazemi, Bronwyn E. Hamilton, and Edward A. Neuwelt. Dual Contrast Perfusion MRI in a Single Imaging Session for Assessment of Pediatric Brain Tumors. Journal of Neuro-Oncology. 2012; 109(1):105-14.

Colin M. Roberts, Eric M. Thompson, and Nathan R. Selden. Transendoscopic Intraoperative Recording of Gelastic Seizures from a Hypothalamic Hamartoma. Pediatric Neurosurgery, 2011; 47(2):147-151.

Eric M. Thompson, Edit Dosa, Dale F. Kraemer, and Edward A. Neuwelt. Correlation of MRI Sequences to Assess Progressive Glioblastoma Multiforme Treated with Bevacizumab. Journal of Neuro-Oncology, 2011; 103(2):353-60.

Eric M. Thompson, Eugene P. Frankel, and Edward A. Neuwelt. The Paradoxical Effect of Bevacizumab in the Therapy of Malignant Gliomas. Neurology, 2011; 76(1):87-93.

Eric M. Thompson, Edit Dosa, Dale F. Kraemer, and Edward A. Neuwelt. Treatment with Bevacizumab Plus Carboplatin for Recurrent Malignant Glioma. Neurosurgery, 2010; 67(1):87-93.

Tammy J. Westmoreland, Jeffrey R. Marks, John A. Olson Jr., Eric M. Thompson, Michael A. Resnick and Craig B. Bennett. Cell Cycle Progression in G1 and S Phases Is CCR4 Dependent Following Ionizing Radiation or Replication Stress in Saccharomyces cerevisiae. Eukaryotic Cell, 2004; 3(2):430–446.