Andrew Hardigan, MD, PhD

Andrew Hardigan

Education

University of Alabama at Birmingham, MD, 2020
University of Alabama at Birmingham, PhD, Genetics, 2018
Colby College, BA, Biology 2010

Research Interests

Functional genomics and gene-editing, brain tumor immunotherapy

Hobbies

Cooking, Brazilian Jiu-Jitsu, rowing

Awards and Honors

2018     Reviewer’s Choice Poster Award, American Society of Human Genetics Conference, San Diego, CA

2017    Poster Award, UAB RNA Biology Symposium

2016    1st Place Oral Presentation, Southeastern Medical Scientists Symposium, Birmingham AL

2016    2nd Place Poster Award in Genetics Research, Medical Student Research Day

2010     Cum Laude, Distinction in the Biology Major

2010     Phi Beta Kappa Honor Society

2009    1st Place, Consulate General of Japan in Boston Essay Contest (Intermediate Division)

2009    Colby College Kim Miller Award For Citizenship and Service

Publications

  1. Ramaker RC*, Hardigan AA*, Partridge EC, Chhetri SB, Newberry KM, Goh S, Wold B, Mendenhall E, Cooper SJ, Myers RM. Dissecting the Regulatory Activity and Sequence Content of Loci With Exceptional Numbers of Transcription Factor Associations.  Genome Research. Jul 2; gr.260463.119
  2. Chagoya, G*, Hardigan AA*, Fox BM, Laskay NMB, Salehani AA, Rotman LE, Elsayed GA, Bernstock JD, Omar NB, Tabibian, BE, Ilyas A, Hackney J, Fisher WS. Cerebellar arteriovenous malformation rupture despite apparent angiographic obliteration: a case repor. World Neurosurgery. 2020 Feb; 134:25-32
  3. Bernstock JD, Shafaat O, Hardigan AA, Fox BM, Moore L, Chagoya G, Elsayed G, Gessler F, Ilyas A, Yamashita D, McGrew B, Fisher W, Hackney J. Angiosarcoma of the temporal bone: case report and review of the literature. World Neurosurgery. 2019 Oct 130:351-357
  4. Hardigan AA, Roberts BS, Moore DE, Ramaker RC, Jones AL,  Myers RM. CRISPR/Cas9 targeted removal of unwanted sequences from small-RNA sequencing libraries. Nucleic Acids Research. 2019 Aug 22:47(14):e84
  5. Hiatt S, Neu MB, Ramaker RC, Hardigan AA, Prokop JW, Hancarova M, Prchalova D, Havlovicova M, Prchal J, Stranecky V, Yim DKC, Powis Z, Keren B, Nava C, Mignot C, Rio M, Revah-Politi A, Hemati P, Stong N, Iglesias AD, Suchy SF, Willaert R, Wentzensen IM, Wheeler PG, Brick L, Kozenko M, Hurst ACE, Wheless JW, Lacassie Y, Sedlacek Z, Myers RM, Barsh GS, Cooper GM. De novo mutations in the GTP/GDP-binding region of RALA, a RAS-like small GTPase, cause intellectual disability and developmental delay. PLoS Genet. 2018 Nov 30;14(11)
  6. Roberts BS, Hardigan AA, Moore DE, Ramaker RC, Jones AL, Fitz-Gerald MB, Cooper GM, Wilcox CM, Kimberly, RP, Myers RM. Discovery and validation of circulating biomarkers of colorectal adenoma by high-depth small RNA sequencing. Clinical Cancer Research. 2018 May 1:24(9):2092-2099
  7. Ramaker RC, Savic D, Hardigan AA, Newberry K, Cooper GM, Myers RM, Cooper SJ. A genome-wide interactome of DNA-associated proteins in the human liver. Genome Res. 2017 Nov; 27(11):1950-1960.
  8. Ramaker RC, Bowling KM, Lasseigne BN, Hagenauer MH, Hardigan AA, Davis NS, Gertz J, Cartagena PM, Walsh DM, Vawter MP, Jones EG, Schatzberg AF, Barchas JD, Watson SJ, Bunney BG, Akil H, Bunney WE, Li JZ, Cooper SJ, Myers RM. Post-mortem molecular profiling of three psychiatric disorders. Genome Med. 2017 Jul 28;9(1):72
  9. Ramaker RC, Lasseigne BN, Hardigan AA, Palacio L, Gunther DS, Myers RM, Cooper SJ. RNA sequencing-based cell proliferation analysis across 19 cancers identifies a subset of proliferation-informative cancers with a common survival signature. 2017 Jun 13;8(24):38668-38681
  10. Alonso A, Lasseigne BN, Williams K, Nielsen J, Ramaker RC, Hardigan AA, Johnston B, Roberts BS, Cooper SJ, Marsal S, Myers RM. aRNApipe: A balanced, efficient and distributed pipeline for processing RNA-seq data in high performance computing environments. Bioinformatics. 2017 Jun 1;33(11):1727-1729
  11. Harms FL*, Girisha KM*, Hardigan AA*, Kortüm F, Shukla A, Alawi M, Dalal A, Brady L, Tarnopolsky M, Bird LM, Ceulemans S, Bebin M, Bowling KM, Hiatt SM, Lose EJ, Primiano M, Chung WK, Juusola J, Akdemir ZC, Bainbridge M, Charng WL, Drummond-Borg M, Eldomery MK, El-Hattab AW, Saleh MA, Bézieau S, Cogné B, Isidor B, Küry S, Lupski JR, Myers RM, Cooper GM, Kutsche K. Mutations in EBF3 Disturb Transcriptional Profiles and Cause Intellectual Disability, Ataxia, and Facial Dysmorphism. Am J Hum Genet. 2017 Jan 5;100(1):117-127              
  12. Engel KL, Mackiewicz M, Hardigan AA, Myers RM, Savic D. Decoding transcriptional enhancers: Evolving from annotation to functional interpretation. Semin Cell Dev Biol. 2016; 57:40-50
  13. Roberts BS, Hardigan AA., Kirby MK, Fitz-Gerald MB, Wilcox CM, Kimberly RP, and Myers RM. Blocking of targeted microRNAs from next-generation sequencing libraries. Nucleic Acids Res. 2015; 2;43(21)
  14. Geraghty P, Hardigan AA, and Foronjy RF. Cigarette smoke activates the proto-oncogene c-src to promote airway inflammation and lung tissue destruction. Am. J. Respir. Cell Mol. Biol. 2014; 50, 559–70.
  15. Geraghty P, Hardigan AA, Wallace AM, Mirochnitchenko O, Thankachen J, Arellanos L, Thompson, V, D’Armiento JM, and Foronjy,R. The glutathione peroxidase 1-protein tyrosine phosphatase 1B-protein phosphatase 2A axis. A key determinant of airway inflammation and alveolar destruction. Am. J. Respir. Cell Mol. Biol. 2013; 49, 721–30.
  16. D’Armiento JM, Goldklang MP, Hardigan AA, Geraghty P, Roth MD, Connett, JE, Wise RA, Sciurba FC, Scharf SM, Thankachen J, et al. Increased Matrix Metalloproteinase (MMPs) Levels Do Not Predict Disease Severity or Progression in Emphysema. PLoS One. 2013; 8. (2):e56352
  17. Mehra D, Geraghty PM , Hardigan AA, and Foronjy RF. A Comparison of the Inflammatory and Proteolytic Effects of Dung Biomass and Cigarette Smoke Exposure in the Lung. PLoS One. 2012;7(12):e52889
  18. Wallace AM, Hardigan A, Geraghty P, Salim S, Gaffney A, Thankachen J, Arellanos L, D’Armiento JM, and Foronjy RF. Protein phosphatase 2A regulates innate immune and proteolytic responses to cigarette smoke exposure in the lung. Toxicol. Sci. 2012; 126, 589–99.

* Indicated Co-First Author