Duke Endovascular Research Lab

The Endovascular Research Lab pursue minimally invasive endovascular—through the artery—methods of treating aneurysms in the brain. Led by L. Fernando Gonzalez, MD, the lab seeks to identify methods to expedite aneurysm occlusion and decrease antiplatelet medications.

Research Projects

  • Endothelial cells - Our research has involved coating metal stents with endothelial cells to try to jump start healing in the artery. We’ve had successful trials in vitro, and will soon begin in vivo research.
  • Interactive 3D fluid dynamics for cerebral aneurysm treatment planning – In collaboration with Amanda Randles from Duke Biomedical Engineering), we are developing computer models to simulate flow based on patient-specific anatomies. We create an aneurysm in a computer and simulate the effect of treatment. This work is supported by a Collaborative Quantitative Approaches to Problems in the Basic and Clinical Sciences grant from Duke.

Clinical Trials

We are involved in several clinical trials as part of our overall translational research efforts.

  • APOLLO - Use of special implantable catheter for AVM embolization 
  • Enterprise - Evaluates the use of a stent in the treatment of cerebral aneurysm
  • CREST 2 - Randomized trial that evaluates the use of carotid stent, carotid endarterectomy and medical treatment for asymptomatic carotid stenosis
  • MISTIE - Randomized trial that evaluates intracerebral catheter infusion of tPA vs. medical therapy for cerebral hematomas

Personnel

L. Fernando Gonzalez, MD
Department of Neurosurgery

George Truskey, PhD
Duke Biomedical Engineering

Jeffrey Lawson, MD, PhD
Duke Department of Surgery

James Otto, PhD
Graduate student, Surgery Research

Contact Us

For more information, please contact L. Fernando Gonzalez at fernando.gonzalez@duke.edu.