iSAH Agenda

Preliminary Agenda

Revised Feb.23, 2023

International Conference on Subarachnoid Hemorrhage
Duke University, Department of Neurosurgery

Friday, June 16, 2023                    

1:00-1:10 pm                                                Introductions and opening remarks, Washington Duke Inn                                  
1:10-1:30 John Zhang, MD, PhD: History of aneurysmal SAH research

Oral Abstract Session with Junior Scientists and Clinician-Scientists

Tatsat Patel, PhD: Novel deep-learning methods for cerebral vessel and aneurysm segmentation

Redi Rashmani, MD: ABT263 senolysis for the prevention of intracranial aneurysm rupture in mice

Freddie Ewbank, PhD: (TBA)

Kerry Poppenberg, PhD: Analyzing epigenetic landscapes around IA haplotypes to understand genetic risk

Sricharan Veeturi, PhD: Quantitative imaging biomarkers for cerebral aneurysm risk stratification

3:30-3:50 Break
3:50-4:10 Yong Jiang, MD, PhD: Disequilibrium of metabolic homeostasis after SAH
4:10-4:30 Hiroki Uchikawa, MD,PhD: Pretreatment with clodronate improved neurofunction involving in inhibition of cerebral blood flow reduction in rat SAH
4:30-4:50 Gang Chen, MD, PhD: How the neuro-glial network responds to subarachnoid hemorrhage
4:50-5:10 Rebecca Heinz, MD: Toll-like receptor4-pathway in neuroinflammation after SAH – possible future targets
5:10-5:30 Ulf C. Schneider, MD: The role of extracellular RNA for microglia activation after SAH
5:30-5:50 Sepideh Amin-Hanjani, MD: AHA/ASA guidelines form management of SAH
5:50-6:10 Jens P. Dreier, MD, PhD: Brain Discharge - 1
6:30-8:30.                  Cocktails and hors d'oeuvres, Washington Duke Hotel

Saturday, June 17

6:45-7:40 am Breakfast
Biomarkers of Subarachnoid Hemorrhage  
7:40-8:00 am Emanuela Keller, MD: Prediction and detection of delayed cerebral ischemia in high-grade SAH patients
8:00-8:20 am H Alex Choi, MD: Biomarkers of cerebral edema after subarachnoid hemorrhage
8:20-8:40 am Sherry Hsiang-Yi Chou, MD: MicroRNA Endotypes in SAH
8:40-9:00 am George Kwok Chu Wong, MD: miRNA Predictors after aneurysmal subarachnoid hemorrhage
9:00-9:20 am Elisa Cudrado-Godia, MD, PhD: GWAS and vasospasm and DCI
9:20-9:40 am Diederik Bulters, MD: GWAS of outcome after SAH
9:40--10:00 am Robert Lock MacDonald, MD: A machine-learning approach to definition and thresholds for intervention for DCI
10:00-10:15 am Mahmud Bossa-Basha, MD: Shortcomings of conventional aneurysm imaging and the value of advanced imaging for aneurysm and vasospasm management
10:15-10:40 Break
Novel Therapeutics 1  
10:40-11:00 am Ian Galea, MD: Hemoglobin and haptoglobin: From basic science to clinical implications for SAH
11:00-11:20 am Michael Hugelshofer, MD: CSF-Hemoglobin after aSAH: biomarker and therapeutic target
11:20-11:35 am Jin Pyeong Jeon MD, PhD: Beyond genetics: Haptoglobin alpha isoform expression and outcome after SAH
11:35-11:50 am Spiros Blackburn, MD: Haptoglobin genetics and outcome after SAH
11:50-12:00 pm Soham Bandyopadhyay, MBBS: Research priorities in haptoglobin clinical translation: A Delphi-based consensus
12:00 -12:50 pm Lunch
Novel Therapeutics 2  
12:50-1:10 pm Thierno Madjou Bah, PhD: GPR39 as a therapeutic target in SAH
1:10-1:30 pm  Stephan Mayer, MD: Taming the autonomic storm after SAH
1:30-1:50 pm Daniel Laskowitz, MD: Selective NMDA inhibitors in high-risk aSAH: Neuroprotection revisited

Lifetime Achievement Award

James Torner, PhD: What have previous clinical trials taught us?

Inflammation and SAH 1  
2:30-2:50 pm Tomoki Hashimoto, MD: Translational research of intracranial aneurysm
2:50-3:10 pm Devin McBride, PhD: Role of platelets after SAH
3:10-3:40 Break
Inflammation and SAH 2  
3:40-3:55 pm Aaron M. Gusdon, MD: Systemic metabolic alterations after aneurysmal subarachnoid hemorrhage
3:55-4:10 pm Naoki Kaneko, MD, PhD: How do endothelial cells respond to flow in cerebral aneurysms?  Bridging computational flow dynamics and endothelial biology
4:10-4:25 pm Wonjae Lee, PhD: Microfluidic neurovascular unit model for precision medicine
4:25-4:40 pm Moinak Banerjee, MD; Genetics, epigenetics and metabolomics of iSAH: an Indian perspective                 
SAH Recovery  
4:40-4:55 pm Wayne Fang, MD: The road to recovery post aSAH
4:55-5:10 pm Sheila A. Alexander, PhD, RN: Omics of recovery from aSAH
6:00-9:00 pm Dinner, JB Duke Hotel

Sunday, June 18

6:40-7:35 am              Breakfast                                                      
Clinical Trials 1    
7:40-7:55 am                            Isabel Charlotte Hostettler, MD, PhD:  Influenceable factors in aneurysmal subarachnoid hemorrhage: Is there a light at the end of the tunnel after all?
7:55-8:10 am                                                                                                   Mervyn D.I. Vergouwen, MD, PhD:  Complement C5 Antibodies for decreasing brain injury after aneurysmal Subarachnoid Hemorrhage (CLASH): a randomized controlled phase IIa clinical trial
8:10-8:25 am Philippe Bijenga, MD, PhD: How to compensate for bias when using health data based on Bayes’ theorem
8:25-8:40 am Alejandro A. Rabinstein, MD:  Antifibrinolytics in aSAH: Case closed?
8:40-8:55 am David Hasan, MD:  iSPASM-1
8:55-9:10 am Jose I Suarez, MD: Variance in care of SAH patients
9:10-9:25 am Anthony Delaney, MBBS, MSc, PhD: The future of clinical trials for aSAH: Where should we stand?
9:25-9:40 am Jose Javier Provencio, MD: TBA
9:40-9:55 am Stefan Wolf, MD: TBA                        
9:55-10:20 am Break
Clinical Trials 2  
10:20-10:35 am Chris Anderson, PhD:  Development of a core outcome set for patients with aneurysmal subarachnoid hemorrhage
10:35-10:50 am Emily Fitzgerald, PhD:  A systematic review assessing the association between method of outcome assessment and reported outcomes in SAH patients
10:50-11:05 am                                                                    Lachlan Donaldson MBBS (Hons) MPhil FCICM: The reported incidence of cerebral arterial vasospasm following aneurysmal subarachnoid hemorrhage is highly variable, and a consensus definition is required: A systematic review and meta-analysis
11:05-11:20 am Shane English,MD:  SAHaRA trial
11:20-11:35 am Ketan R. Bulsara, MD, and Rock Chen, MD: The intra-arterial vasospasm trial
11:35-11:50 am Michael Veldeman, MD, PhD: Intra-arterial spasmolysis for the treatment of delayed cerebral ischemia: What do we achieve by making vessels wide?
12:00 am-12:40 pm Lunch
Clinical Trials 3                 
12:40-12:55 pm Hemant Bhagat, MD: aSAH and anesthesia: Current understanding
12:55-1:10 pm Behnam Rezai Jahromi, MD: Vasospasm and shunt dependency with active CSF exchange
1:10-1:25 pm Miriam Treggiari, MD, PhD: Cervical sympathetic blockade to manage cerebral vasospasm
1:25-1:40 pm Christine Buckley: The need for center of excellence designation to improve patient outcome
1:40-2:20 pm

iSAH 2023 Honored Guest Speaker

Gabriel Rinkle, MD: Insights on future research in SAH

Unruptured Aneurysms 1  
2:20-2:35 pm Yuichi Murayama, MD: Computational fluid dynamic analysis of the initiation of cerebral aneurysms: Experimental and human studies
2:35-2:50 pm Aichi Chien, PhD: Longitudinal changes in human brain aneurysms
2:50-3:05 pm Anne M. Robertson, PhD: Engineering and materials science mechanobiology of cerebral aneurysm blebs
3:05-3:30 Break
Unruptured Aneurysms 2  
3:30-3:45 pm Edgar A Samaniego, MD, MSc: What can we learn from determining the enhancement of the aneurysm wall?
3:45-4:00 pm Vincent M. Tutino, PhD: Circulating molecular signatures of Intracranial aneurysm
4:00-4:15 pm Nima Etminan, MD: Risk factor modification as a therapeutic target in unruptured intracranial aneurysms
4:15-4:30 pm Soichiro Fujimura, PhD: AI for prediction of unruptured intracranial aneurysms (Japan, US, European multicenter study)
4:30-4:45 pm Jingfeng (JJ) Jiang, PhD: Artificial intelligence-augmented computational hemodynamic analysis of intracranial aneurysms
4:45-5:00 pm Closing remarks and announcement of iSAH 2025 in Hong Kong